Diazepam for pelvic floor dysfunction

Vaginal Diazepam for Nonrelaxing Pelvic Floor Dysfunction: The Pharmacokinetic Profile Vaginal administration of diazepam results in lower peak serum plasma concentration, longer time to peak concentration, and lower bioavailability than standard oral use A study evaluating charts of 26 patients who were given diazepam suppositories as adjuvant therapy for PFD and sexual pain, found that 25 out of 26 patients reported clinically significant improvement with the suppositories. Use of the diazepam suppositories also improved sexual pain and tone of the pelvic floor muscle Vaginal diazepam is used off-label for pelvic floor dysfunction and urogenital pain, but serum levels with efficacy have not been reported until now. One clinician evaluated 21 women for overall, levator, and vulvar pain pre- and one-month post-daily diazepam treatment Larish AM, Dickson RR, Kudgus RA, et al. Vaginal Diazepam for Nonrelaxing Pelvic Floor Dysfunction: The Pharmacokinetic Profile. J Sex Med 2019;16;763-766., keywords = Chronic Pelvic Pain, Diazepam, Dyspareunia, Nonrelaxing Pelvic Floor Dysfunction, Pelvic Floor Dysfunction, Pelvic Pain Vaginal diazepam is a widely used treatment for pelvic pain, specifically nonrelaxing or hypertonic pelvic floor dysfunction

Vaginal Diazepam for Nonrelaxing Pelvic Floor Dysfunction

  1. e the efficacy of intravaginal diazepam for the treatment of pelvic pain associated with pelvic floor hypertonic disorder
  2. istration (FDA) approval for use as a muscle relaxant
  3. A diazepam suppository is a small white, waxy, bullet-shaped pellet that can be inserted in either the vagina or the bowel. It can help relax the muscles and settle the spasm. They aren't suitable for regular use, but can be useful for occasional bad days when you have a flare of pain. The other name for diazepam is valium
  4. Literature suggests that the pelvic floor muscles contribute to CPP in women as both the primary pain generator and as a compensatory contributor.3, 4 Pelvic floor dysfunction (PFD) may occur as a result of inherent musculoskeletal causes in the pelvic floor muscles, ligaments and tendons or PFD may occur as a functional adaptation to other.
  5. Currently, some doctors are prescribing vaginal diazepam (Valium) suppositories or tablets to help relieve the pain of pelvic floor dysfunction, interstitial cystitis, vulvar pain, and sexual pain. This causes less drowsiness as a side effect than oral valium, but nevertheless it may still produce mild sedation [

Many people with pelvic pain have pelvic floor dysfunction, but specifically hypertonic muscles, or muscles that are too tight. The pelvic floor muscles are a group of muscles that attach to the front, back and sides of the bottom of the pelvis and sacrum. Medication such as compounded vaginal or rectal diazepam can be quite helpful and may. The pelvic floor is comprised of muscles and fascia and has three functions: support of the pelvic organs, contraction, and relaxation. Their function is critical to proper micturition, defecation, and sexual intercourse. In the past, pelvic floor dysfunction (PFD) has been variously termed spastic pelvic floor syndrome, levator ani syndrome. Relaxing the muscles in the pelvic floor area overall is important. Using methods such as warm baths at least twice a day is helpful. Medicines—Low doses of muscle relaxants such as diazepam (Valium), 2 mg three times a day, may be helpful Dr Susan Evans is a Gynaecologist, Laparoscopic Surgeon and Specialist Pain Medicine Physician in Adelaide, with particular interest in the management of pelvic pain. She is the author of the book 'Endometriosis and Pelvic Pain' and co-author of the policy document 'The $6Billion Woman and the $600 Million Girl: The Pelvic Pain Report'

Diazepem and Pelvic Floor Dysfunction - CareFirst

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